Recombinant human bone morphogenetic protein-2/atelocollagen composite as a new material for ossicular reconstruction
نویسندگان
چکیده
منابع مشابه
Use of recombinant human bone morphogenetic protein 2 for mandible reconstruction.
BACKGROUND Microvascular osseous free tissue transfer is the standard of care for reconstructing significant mandibulectomy defects; however, this procedure can carry a significant rate of morbidity. OBJECTIVES To describe the use of recombinant human bone morphogenetic protein 2 (rhBMP-2) as an option for segmental or near-complete rim mandibulectomy defects in a select group of patients, pr...
متن کاملBone cements as adjuvant techniques for ossicular chain reconstruction.
HYPOTHESIS The osseointegrative capacity of medical-grade bone cement can be used to improve fixation and prevent displacement of an ossicular prosthesis in a guinea pig model. BACKGROUND Successful ossiculoplasty requires a firm connection between the vibrating tympanic membrane and the inner ear. In patients requiring revision ossiculoplasty, half of failures are due to prosthesis displacem...
متن کاملAccelerators of Osteogenesis by Recombinant Human Bone Morphogenetic Protein-2
Bone morphogenetic protein (BMP) appears to be one of the most promising cytokine and for clinical use in reconstructive surgery for bony defects and augmentation. To evaluate the effect of basic fibroblast growth factor (bFGF), FK506, elcatonin, and hyperbaric oxygenation (HBO) on osteoinduction by recombinant human bone morphogenetic protein-2 (rhBMP-2), 2 or 5 μg of rhBMP-2 was implanted int...
متن کاملOff-label use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for reconstruction of mandibular bone defects in humans.
PURPOSE The off-label use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for the treatment of mandibular bone defects was evaluated in 5 patients. The rhBMP-2 was used as an alternative to autogenous bone grafting. PATIENTS AND METHODS A total of 5 patients had mandibular defects reconstructed with rhBMP-2, 1.5 mg/mL, soaked collagen sponges alone or in combination with bone marr...
متن کاملMedical Policy Recombinant Human Bone Morphogenetic Protein (rhBMP) for Bone Fusion
*(Unfeasible is defined as autograft is no longer available because of prior use or insufficient tissue or the candidate is unacceptable because of any of the following reasons obesity, over 65 years of age, morbidity preventing harvesting at autograft donor site (infection, fracture), excessive risk of anatomic disruption from harvesting, osteoporosis, concurrent medical conditions and co-morb...
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ژورنال
عنوان ژورنال: Journal of Biomedical Materials Research Part A
سال: 2009
ISSN: 1549-3296,1552-4965
DOI: 10.1002/jbm.a.31971